Paediatrics trials

The prognosis for young people diagnosed with T1D during childhood remains poor and this may relate to the higher HbA1c levels encountered during puberty. MA identifies subjects at risk for DN and CVD and it is often observed in adolescent…

Nocturnal hypoglycaemia is a serious complication of insulin treatment in subjects with type 1 diabetes (T1D) and it represents a critical problem in the management of the disease. Severe episodes of hypoglycaemia occurring overnight can…

The majority of adolescents and young adults with type 1 diabetes now use a basal bolus insulin regime (once or twice daily long acting insulin with multiple injections of short or rapid acting insulin given with food) in an attempt to optimise…

Congenital cataract is the main treatable cause of global childhood blindness. 'Red-reflex' assessment with an ophthalmoscope during the UK Newborn and Infant Physical Examination (NIPE) screening…

MELD-ATG is a multi-centre, randomised, double-blind, placebocontrolled, multi-arm parallel cohort trial. The purpose of this clinical trial is to confirm the effect of 2.5mg/kg of antithymocyte globulin (ATG) on the preservation of stimulated C-…

Increasing numbers of infants are being born preterm, particularly of very low birth weight. These infants require intensive care and have a high risk of short term mortality and morbidity. Surviving infants have a high incidence of long term…